Purpose/Significance To construct a database for the full-process management of pulmonary nodules/lung cancer, to achieve full-process management and scientific research support, in order to promote technological innovation and development in the diagnosis and treatment of pulmonary nodules/lung cancer.Method/Process A tripartite co-construction and sharing model involving the clinical team, integrated care management center, and information center is adopted. According to the development stages of disease diagnosis and treatment, the database is divided into four sub databases, and prospective and retrospective data are integrated to construct a database for the full-process management of specialized diseases.Result/Conclusion Since its establishment in 2022, as of July 1,2025, this database has included 36 262 patients. The database breaks through the traditional research project driven model and achieves full life-cycle information tracking from the discovery of pulmonary nodules to treatment and rehabilitation, providing a new paradigm for the construction of specialized disease databases.