Purpose/Significance To design the overall framework of the public health emergency command system, so as to promote the construction and improvement of the public health emergency management system in China. Method/Process By using methods such as literature review, on-site investigation and technical analysis, the design goals and overall framework design principles of the public health emergency command system are expounded, and the overall framework of the system is designed. Result/Conclusion The overall framework design of the public health emergency command system follows five major principles and adopts eight key technologies, forming an overall framework of “six layers, three systems and two interconnections”. This system can enhance the handling efficiency and command capability of the emergency management department.