Purpose/Significance To explore the strategies for constructing a data-sharing platform for the full-chain of high-quality development of Shanghai’s innovative drug industry, so as to promote the digital transformation and high-quality development of the innovative drug industry. Method/Process The existing problems of data management in Shanghai’s innovative drug industry are analyzed. A comprehensive full-chain data-sharing platform architecture is proposed, covering the infrastructure layer, technical support layer, application module layer, and user interaction layer. Result/Conclusion The construction of this data-sharing platform can systematically address the data disconnection issues, achieve closed-loop management of the entire lifecycle data from drug research and development to production and clinical use. It will enhance the efficiency and quality of the innovative drug industry and provide data support for personalized medicine.