Purpose/Significance To explore the specific implementation path of microservice architecture in smart hospital information system, and to improve the quality of medical services and operational efficiency. Method/Process By adopting the case analysis method and in combination with relevant standards, a “modular+plug-in” framework is proposed. Through practical analysis, the integrated implementation path and reusable strategies are systematically summarized.Result/Conclusion The path significantly enhances iterative efficiency and scalability in high-frequency scenarios such as outpatient and emergency services, improves data consistency and fault isolation capabilities, and is compatible with domestic databases. It provides reusable methodological references for the transformation of microservices in smart hospitals.