Purpose/Significance To explore the innovative talent cultivation model in bioinformatics, and to provide an important reference for the cultivation of innovative talents in this discipline in the era of intelligent medicine. Method/Process A curriculum system deeply integrating artificial intelligence (AI) and bioinformatics is established. Practical teaching that integrates knowledge imparting, ability enhancement and quality cultivation is carried out. An evaluation system oriented towards innovation and practical ability is restructured. The ability of AI among the teaching staff is improved. Through the above countermeasures, a path for the cultivation of emerging interdisciplinary talents in the field of intelligent medicine is explored. Result/Conclusion This path provides a favorable theoretical and practical environment for the growth of compound talents and improving the quality of talent cultivation.