Purpose/Significance To analyze the application of artificial intelligence (AI) and other information technologies in public health emergency management, and to provide references for the construction of a smart public health emergency management system. Method/Process Based on the intelligent needs of public health emergency management, an in-depth analysis of the application scenarios and challenges of AI in public health emergency management is conducted. Result/Conclusion AI plays a key role in stages of public health emergency prevention and preparation, monitoring and early warning, disposal and rescue, recovery and reconstruction, etc. However, challenges remain in data governance, model algorithms and privacy protection, as well as management-technology compatibility issues. Corresponding measures should be taken to reduce the risks of AI applications and enhance its application value in public health emergency management.