Purpose/Significance To explore the key factors and their configurations influencing the pseudo-health information dissemination behavior of social network users, and to provide references for purifying the social network space. Method/Process Based on the stimulus-organism-response (SOR) theoretical framework, structural equation model (SEM) and fuzzy-set qualitative comparative analysis (fsQCA) are used to investigate the key factors and configurations that influence the dissemination of pseudo-health information by social network users. Result/Conclusion The quantity and quality of information negatively affect risk perception but positively affect involvement; authority effect negatively affects health anxiety but positively affects knowledge level; involvement, trust perception and online health anxiety all positively affect the dissemination of pseudo-health information, while risk perception, health literacy and knowledge level all negatively affect the dissemination of pseudo-health information. Two types of configuration paths for the dissemination of pseudo-health information are identified, namely cognitive kinetic energy-dominated and emotion-driven collaborative.